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Article

Effects of Cytochrome P450 Inhibition and Induction on the Phenotyping Metrics of the Basel Cocktail: A Randomized Crossover Study.

Clinical pharmacokinetics - 1 Jan 2016

Derungs Adrian, Donzelli Massimiliano, Berger Benjamin, Noppen Christoph, Krähenbühl Stephan, Haschke Manuel

Abstract excerpt

BACKGROUND AND OBJECTIVE: Activity of human cytochrome P450 enzymes (CYPs) shows high inter-and intra-individual variability, which is determined by genetic and non-genetic factors. Using a combination of CYP-specific probe drugs, phenotyping cocktails allow simultaneous assessment of the activity of different CYP isoforms. The objective of this study was to characterize the phenotyping metrics of the Basel...

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Identifiers

PMID: 26123704
DOI: 10.1007/s40262-015-0294-y
PMCID: PMC4712254

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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