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Article

A pathway that links reproductive status to lifespan in <i>Caenorhabditis elegans</i>

1 Aug 2010

Abstract excerpt

In the nematode Caenorhabditis elegans and the fruit fly Drosophila, loss of the germline stem cells activates lifespan-extending FOXO-family transcription factors in somatic tissues and extends lifespan, suggesting the existence of an evolutionarily conserved pathway that links reproductive state and aging. Consistent with this idea, reproductive tissues have been shown to influence the lifespans of mice and...

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PMID: 20738286
DOI: 10.1111/j.1749-6632.2010.05640.x

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