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Article

RPN-6 determines C. elegans longevity under proteotoxic stress conditions.

Nature - 13 Sept 2012

Vilchez David, Morantte Ianessa, Liu Zheng, Douglas Peter M, Merkwirth Carsten, Rodrigues Ana P C, Manning Gerard, Dillin Andrew

Abstract excerpt

Organisms that protect their germ-cell lineages from damage often do so at considerable cost: limited metabolic resources become partitioned away from maintenance of the soma, leaving the ageing somatic tissues to navigate survival amid an environment containing damaged and poorly functioning proteins. Historically, experimental paradigms that limit reproductive investment result in lifespan extension. We...

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PMID: 22922647
DOI: 10.1038/nature11315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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