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Article

Twenty-four non-synonymous polymorphisms in the one-carbon metabolic pathway and risk of colorectal adenoma in the Nurses' Health Study.

Carcinogenesis - 1 Jul 2007

Hazra Aditi, Wu Kana, Kraft Peter, Fuchs Charles S, Giovannucci Edward L, Hunter David J

Abstract excerpt

Dietary folate and alcohol consumption as well as polymorphic variants in one-carbon metabolism genes may modulate risk of colorectal adenoma through aberrant DNA methylation and altered nucleotide synthesis and repair. We assessed the association of 24 non-synonymous single nucleotide polymorphisms (nsSNPs) in 13 genes in the one-carbon metabolism pathway and risk of colorectal adenoma in 556 incident cases and...

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Source

Identifiers

PMID: 17389618
DOI: 10.1093/carcin/bgm062

Genes

MTRR
BHMT

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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