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Article

Associations between genes in the one-carbon metabolism pathway and advanced colorectal adenoma risk in individuals with low folate intake.

Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Mar 2012

Han Summer S, Sue Laura Y, Berndt Sonja I, Selhub Jacob, Burdette Laurie A, Rosenberg Philip S, Ziegler Regina G

Abstract excerpt

BACKGROUND: Folate is essential for one-carbon metabolism, a pathway required by DNA synthesis, methylation, and repair. Low dietary and circulating folate and polymorphic variation in this pathway are associated with increased risk of colorectal adenoma and cancer. METHODS: We genotyped 882 sing...

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PMID: 22253295
DOI: 10.1158/1055-9965.EPI-11-0782

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ADA
CDO1
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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22253295-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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