Germline polymorphisms in the one-carbon metabolism pathway  and DNA methylation in colorectal cancer.

doi:10.1007/s10552-009-9464-2

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Article

Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.

Cancer causes & control : CCC - 1 Mar 2010

Hazra Aditi, Fuchs Charles S, Kawasaki Takako, Kirkner Gregory J, Hunter David J, Ogino Shuji

Abstract excerpt

Dietary intake of one-carbon nutrients (methyl donors) and germline variants in the one-carbon metabolism genes may influence global DNA methylation level and methylation in promoter CpG islands. In this study, we evaluated the relationship between single nucleotide polymorphisms (SNPs) in the one-carbon metabolism pathway and DNA methylation status in colorectal cancer. Utilizing 182 colorectal cancers cases in...

Topics

Aged
Colorectal Neoplasms
CpG Islands
DNA Methylation
Female
Germ-Line Mutation
Humans
Long Interspersed Nucleotide Elements
Male
Methylenetetrahydrofolate Reductase (NADPH2)
Microsatellite Repeats

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Odds Ratio

Phenotype

Polymerase Chain Reaction

Polymorphism, Single Nucleotide

Prospective Studies

Transcobalamins

Source

Open in PubMed Open full text

Identifiers

PMID: 19936946
DOI: 10.1007/s10552-009-9464-2
PMCID: PMC3570978

Genes

MTHFR
TCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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