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Article

Germline polymorphisms in the one-carbon metabolism pathway and DNA methylation in colorectal cancer.

Cancer causes & control : CCC - 1 Mar 2010

Hazra Aditi, Fuchs Charles S, Kawasaki Takako, Kirkner Gregory J, Hunter David J, Ogino Shuji

Abstract excerpt

Dietary intake of one-carbon nutrients (methyl donors) and germline variants in the one-carbon metabolism genes may influence global DNA methylation level and methylation in promoter CpG islands. In this study, we evaluated the relationship between single nucleotide polymorphisms (SNPs) in the one-carbon metabolism pathway and DNA methylation status in colorectal cancer. Utilizing 182 colorectal cancers cases in...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 19936946
DOI: 10.1007/s10552-009-9464-2
PMCID: PMC3570978

Genes

MTHFR
TCN2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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