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One-carbon metabolism biomarkers and genetic variants in relation to colorectal cancer risk by KRAS and BRAF mutation status.

PloS one - 1 Jan 2018

Myte Robin, Gylling Björn, Häggström Jenny, Schneede Jörn, Löfgren-Burström Anna, Huyghe Jeroen R, Hallmans Göran, Meyer Klaus, Johansson Ingegerd, Ueland Per Magne, Palmqvist Richard, Van Guelpen Bethany

Abstract excerpt

Disturbances in one-carbon metabolism, intracellular reactions involved in nucleotide synthesis and methylation, likely increase the risk of colorectal cancer (CRC). However, results have been inconsistent. To explore whether this inconsistency could be explained by intertumoral heterogeneity, we evaluated a comprehensive panel of one-carbon metabolism biomarkers and some single nucleotide polymorphisms (SNPs) in...

Topics

Biomarkers, Tumor
Carbon
Case-Control Studies
Colorectal Neoplasms
Cystathionine gamma-Lyase
Female
Gene Regulatory Networks
Genetic Association Studies
Humans
Male

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Middle Aged

Polymorphism, Single Nucleotide

Proto-Oncogene Proteins B-raf

Proto-Oncogene Proteins p21(ras)

Sweden

Source

Open in PubMed Open full text

Identifiers

PMID: 29694444
DOI: 10.1371/journal.pone.0196233
PMCID: PMC5919009

Genes

BRAF
KRAS
CTH

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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