Article
Biomarkers related to one-carbon metabolism as potential risk factors for distal colorectal adenomas.
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology - 1 Aug 2011
de Vogel Stefan, Schneede Jörn, Ueland Per Magne, Vollset Stein Emil, Meyer Klaus, Fredriksen Ase, Midttun Øivind, Bjørge Tone, Kampman Ellen, Bretthauer Michael, Hoff Geir
Abstract excerpt
BACKGROUND: Efficient one-carbon metabolism, which requires adequate supply of methyl group donors and B-vitamins, may protect against colorectal carcinogenesis. However, plasma folate and vitamins B2 and B12 have inconsistently been associated with colorectal cancer risk, and there have been no previous studies relating plasma concentrations of methionine, choline, and betaine to this outcome. METHODS: This...
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