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Article

Mechanism of origin activation by monomers of R6K-encoded pi protein.

Journal of molecular biology - 11 May 2007

Bowers Lisa M, Krüger Ricardo, Filutowicz Marcin

Abstract excerpt

One recurring theme in plasmid duplication is the recognition of the origin of replication (ori) by specific Rep proteins that bind to DNA sequences called iterons. For plasmid R6K, this process involves a complex interplay between monomers and dimers of the Rep protein, pi, with seven tandem iterons of gamma ori. Remarkably, both pi monomers and pi dimers can bind to iterons, a new paradigm in replication...

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Identifiers

PMID: 17383678
DOI: 10.1016/j.jmb.2007.02.074
PMCID: PMC2001305

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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