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Article

Chaperone-mediated reduction of RepA dimerization is associated with RepA conformational change.

Molecular microbiology - 1 Oct 1997

Dibbens J A, Muraiso K, Chattoraj D K

Abstract excerpt

RepA, the initiator protein of plasmid P1, binds to multiple sites (iterons) in the origin. The binding normally requires participation of chaperones, DnaJ, DnaK and GrpE. When purified, RepA appears dimeric and is inactive in iteron binding. On reaction with chaperones, a species active in iteron binding is formed and found to be monomeric. To test whether the chaperones can reduce dimerization, RepA was used to...

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Identifiers

PMID: 9383200
DOI: 10.1046/j.1365-2958.1997.5691920.x

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Chaperone-mediated reduction of RepA dimerization is associated with RepA conformational change.PMID 9383200Read ↗

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