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Article

Cooperative binding mode of the inhibitors of R6K replication, pi dimers.

Journal of molecular biology - 28 Mar 2008

Bowers Lisa M, Filutowicz Marcin

Abstract excerpt

The replication initiator protein, pi, plays an essential role in the initiation of plasmid R6K replication. Both monomers and dimers of pi bind to iterons in the gamma origin of plasmid R6K, yet monomers facilitate open complex formation, while dimers, the predominant form in the cell, do not. Consequently, pi monomers activate replication, while pi dimers inhibit replication. Recently, it was shown that the...

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Identifiers

PMID: 18295232
DOI: 10.1016/j.jmb.2008.01.039
PMCID: PMC2518315

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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