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Article

Replication initiation at a distance: determination of the cis- and trans-acting elements of replication origin alpha of plasmid R6K.

The Journal of biological chemistry - 19 Feb 2010

Saxena Mukesh, Abhyankar Mayuresh, Bastia Deepak

Abstract excerpt

Plasmid R6K, which contains 3 replication origins called alpha, gamma, and beta, is a favorable system to investigate the molecular mechanism(s) of action at a distance, i.e. replication initiation at a considerable distance from the primary initiator protein binding sites (iterons). The centrally located gamma origin contains 7 iterons that bind to the plasmid-encoded initiator protein, pi. Ori alpha, located at...

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Identifiers

PMID: 20018882
DOI: 10.1074/jbc.M109.067348
PMCID: PMC2820798

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