Article
Impaired FHIT expression characterizes serous ovarian carcinoma.
British journal of cancer - 20 Jul 2001
Ozaki K, Enomoto T, Yoshino K, Fujita M, Buzard G S, Kawano K, Yamasaki M, Murata Y
Abstract excerpt
The FHIT (fragile histidine triad) gene on chromosome 3p14.2 is a candidate tumour suppressor gene. To define the role of the FHIT gene in the development of ovarian cancer, we have examined 33 ovarian carcinomas, 2 borderline tumours and 10 benign adenomas for the presence of FHIT gene alterations. FHIT transcripts were analysed by RT-PCR and sequencing. Aberrant FHIT transcripts were observed in 5/33 carcinomas...
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