Article
FHIT gene alterations in esophageal cancer and ulcerative colitis (UC).
Oncogene - 3 Jul 1997
Zou T T, Lei J, Shi Y Q, Yin J, Wang S, Souza R F, Kong D, Shimada Y, Smolinski K N, Greenwald B D, Abraham J M, Harpaz N, Meltzer S J
Abstract excerpt
FHIT (fragile histidine triad gene), a candidate tumor suppressor gene, was recently identified and cloned at chromosome 3p14.2. Alterations of this gene have been reported in a number of primary human tumors, including colorectal, esophageal, gastric and lung carcinomas. However, some reports have found no abnormalities in this gene. We investigated a total of 63 primary esophageal tumors, nine esophageal cancer...
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