Article
Hereditary and acquired p53 gene mutations in childhood acute lymphoblastic leukemia.
The Journal of clinical investigation - 1 Feb 1992
Felix C A, Nau M M, Takahashi T, Mitsudomi T, Chiba I, Poplack D G, Reaman G H, Cole D E, Letterio J J, Whang-Peng J
Abstract excerpt
The p53 gene was examined in primary lymphoblasts of 25 pediatric patients with acute lymphoblastic leukemia by the RNase protection assay and by single strand conformation polymorphism analysis in 23 of 25 cases. p53 mutations were found to occur, but at a low frequency (4 of 25). While all four...
Topics
- Adolescent
- Adult
- Base Sequence
- Burkitt Lymphoma
- Child
- Child, Preschool
- Chromosome Deletion
- Genes, p53
- Humans
- Infant
- Infant, Newborn
- Li-Fraumeni Syndrome
- Molecular Sequence Data
- Mutation
- Polymorphism, Genetic