Article
Absence of hereditary p53 mutations in 10 familial leukemia pedigrees.
The Journal of clinical investigation - 1 Aug 1992
Felix C A, D'Amico D, Mitsudomi T, Nau M M, Li F P, Fraumeni J F, Cole D E, McCalla J, Reaman G H, Whang-Peng J
Abstract excerpt
Germline p53 mutations have been identified in the Li-Fraumeni syndrome but the role of such mutations in familial leukemia is not established. The p53 gene was examined by single-strand conformation polymorphism analysis of exons 4-8 in 10 families with multiple members affected with leukemia. T...
Topics
- DNA, Neoplasm
- Genes, p53
- Humans
- Leukemia
- Mutation
- Pedigree
- Polymerase Chain Reaction
- Restriction Mapping