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Article

Absence of hereditary p53 mutations in 10 familial leukemia pedigrees.

The Journal of clinical investigation - 1 Aug 1992

Felix C A, D'Amico D, Mitsudomi T, Nau M M, Li F P, Fraumeni J F, Cole D E, McCalla J, Reaman G H, Whang-Peng J

Abstract excerpt

Germline p53 mutations have been identified in the Li-Fraumeni syndrome but the role of such mutations in familial leukemia is not established. The p53 gene was examined by single-strand conformation polymorphism analysis of exons 4-8 in 10 families with multiple members affected with leukemia. The diagnoses included acute and chronic leukemias and Hodgkin's disease. Identified in two families were p53 mutations...

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Identifiers

PMID: 1644930
DOI: 10.1172/JCI115907
PMCID: PMC443147

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Absence of hereditary p53 mutations in 10 familial leukemia pedigrees.PMID 1644930Read ↗

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