Article
[Alterations of the p53 gene and clinical features in childhood acute lymphoblastic leukemia].
[Rinsho ketsueki] The Japanese journal of clinical hematology - 1 Sept 1997
Kawamua M, Hayashi Y, Bessho F, Yanagisawa M, Hanada R, Yamamoto K, Horibe K, Hongo T, Ueda K
Abstract excerpt
Correlations between alterations of the p53 gene and clinical features were examined in childhood acute lymphoblastic leukemia (ALL). We analyzed 147 patients and 38 cell lines for p53 mutations within exons 5 to 9 (2 to 11 in some of them) by polymerase chain reaction-single strand conformation polymorphism (PCR-SSCP) analysis and direct sequencing. p53 gene mutations were found in 3 of 62 (5%) patients at...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.