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Article

High incidence of potential p53 inactivation in poor outcome childhood acute lymphoblastic leukemia at diagnosis

1 Feb 1996

Abstract excerpt

Previous studies have indicated that p53 gene mutations were an uncommon event in acute lymphoblastic leukemia (ALL) in children. In one series of 330 patients, p53 mutations were seen in fewer than 3%. We analyzed bone marrow mononuclear cells derived from 10 children with ALL at diagnosis who subsequently failed to achieve a complete remission or who developed relapse within 6 months of attaining complete...

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PMID: 8562942
DOI: 10.1182/blood.v87.3.1155.bloodjournal8731155

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