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Article

TP53 is frequently altered by methylation, mutation, and/or deletion in acute lymphoblastic leukaemia.

Molecular carcinogenesis - 1 Dec 2003

Agirre Xabier, Novo Francisco J, Calasanz María J, Larráyoz María J, Lahortiga Idoya, Valgañón Mikel, García-Delgado Marina, Vizmanos José L

Abstract excerpt

Different mechanisms, such as chromosomal rearrangements, deletions, mutations, and methylation/demethylation of the promoter regions of genes, have been shown to be involved in acute lymphoblastic leukaemia (ALL). These genetic and epigenetic alterations lead to the activation of protooncogenes or to inactivation of tumour suppressor genes promoting cell proliferation. One of the most frequently inactivated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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PMID: 14639659
DOI: 10.1002/mc.10159

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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