Article
Analysis of TP53 mutations in relapsed childhood acute lymphoblastic leukemia.
Journal of pediatric hematology/oncology - 1 Oct 2001
Gump J, McGavran L, Wei Q, Hunger S P
Abstract excerpt
TP53 is the most commonly mutated gene in human cancer, but TP53 mutations are present in less than 5% of children with acute lymphoblastic leukemia (ALL) at initial presentation. Mutations are detected more frequently in children with relapsed T-cell ALL, but the potential role of TP53 mutations in relapsed B-lineage childhood ALL is not understood as well. The authors determined the nucleotide sequence of...
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