Infrequent mutations in the P53 gene in primary human T-cell acute lymphoblastic leukemia.

Abstract excerpt

Alterations of the P53 tumor suppressor gene are present in various human malignancies. P53 mutations have recently been detected in 60% of human T-cell leukemia permanent cell lines. To determine the frequency of P53 mutations in primary T-cell acute lymphoblastic leukemia (T-ALL), a powerful me...

Topics

• Base Sequence
• Chromosomes, Human, Pair 17
• DNA, Neoplasm
• DNA, Single-Stranded
• Genes, p53
• Humans
• Leukemia-Lymphoma, Adult T-Cell
• Molecular Sequence Data
• Mutation
• Polymerase Chain Reaction
• Polymorphism, Genetic
• Precursor Cell Lymphoblastic Leukemia-Lymphoma