Structural and functional analysis of oncogenes and tumor suppressor genes in adult T-cell leukemia/lymphoma shows frequent p53 mutations.

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Article

Structural and functional analysis of oncogenes and tumor suppressor genes in adult T-cell leukemia/lymphoma shows frequent p53 mutations.

Blood - 15 Dec 1992

Cesarman E, Chadburn A, Inghirami G, Gaidano G, Knowles D M

Abstract excerpt

The human T-cell lymphotropic virus type I (HTLV-I) is capable of inducing adult T-cell leukemia/lymphoma (ATLL). However, the long latency period between infection and development of ATLL, as well as the small fraction of the infected population that actually develops this disease, suggest that additional factors are involved in its pathogenesis. Therefore, we performed a molecular analysis of 10 cases of ATLL...

Topics

Alleles
Base Sequence
Blotting, Southern
Bone Marrow
Cloning, Molecular
DNA, Neoplasm
DNA, Viral
Exons
Gene Rearrangement
Gene Rearrangement, beta-Chain T-Cell Antigen Receptor
Genes, Retinoblastoma

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genes, Tumor Suppressor

Genes, myc

Genes, p53

Genes, ras

Genotype

Human T-lymphotropic virus 1

Humans

Source

Open in PubMed

Identifiers

PMID: 1361372

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1361372-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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