Vitamin D receptor 3' haplotypes are unequally expressed in primary human bone cells and associated with increased fracture risk: the MrOS Study in Sweden and Hong Kong.

doi:10.1359/jbmr.070317

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Article

Vitamin D receptor 3' haplotypes are unequally expressed in primary human bone cells and associated with increased fracture risk: the MrOS Study in Sweden and Hong Kong.

Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research - 1 Jun 2007

Grundberg Elin, Lau Edith M C, Pastinen Tomi, Kindmark Andreas, Nilsson Olof, Ljunggren Osten, Mellström Dan, Orwoll Eric, Redlund-Johnell Inga, Holmberg Anna, Gurd Scott, Leung Ping Chung, Kwok Timothy, Ohlsson Claes, Mallmin Hans, Brändström Helena

Abstract excerpt

UNLABELLED: The VDR is a prime candidate gene for osteoporosis. Here, we studied three common VDR haplotypes in relation to bone phenotypes in 5014 participants of the global MrOS Study. We also studied the relative expression of the haplotypes in human bone cells. One haplotype was associated with increased fracture risk and differently expressed in primary human bone cells. INTRODUCTION: Vitamin D plays an...

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PMID: 17371163
DOI: 10.1359/jbmr.070317

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