Article
Vitamin D receptor gene polymorphisms influence on clinical profile and bone mineral density at different skeletal sites in postmenopausal osteoporotic women.
International journal of immunogenetics - 1 Apr 2023
de Azevêdo Silva Jaqueline, de Lima Camilla Albertina Dantas, Guaraná Werbson Lima, Barbosa Alexandre Domingues, Fragoso Thiago Sotero, Duarte Ângela Luzia Branco Pinto, Crovella Sergio, Sandrin-Garcia Paula
Abstract excerpt
Bone remodeling is marked by bone synthesis and absorption balance, and any altered dynamic in this process leads to osteoporosis (OP). The interaction of hormonal, environmental and genetic factors regulate bone metabolism. Since vitamin D displays a classic role in bone metabolism regulation, acting through vitamin D receptor (VDR), the genetic variants within VDR were the first ones associated with bone...
Topics
- Female
- Humans
- Middle Aged
- Bone Density
- Genotype
- Melanins
- Osteoporosis
- Osteoporosis, Postmenopausal
- Polymorphism, Single Nucleotide
- Postmenopause
- Receptors, Calcitriol
- Vitamin D