Article
A survey of haplotype variants at several disease candidate genes: the importance of rare variants for complex diseases.
Journal of medical genetics - 1 Mar 2005
Liu P-Y, Zhang Y-Y, Lu Y, Long J-R, Shen H, Zhao Lan-J, Xu F-H, Xiao P, Xiong D-H, Liu Y-J, Recker R R, Deng H-W
Abstract excerpt
BACKGROUND: The haplotype based association method offers a powerful approach to complex disease gene mapping. In this method, a few common haplotypes that account for the vast majority of chromosomes in the populations are usually examined for association with disease phenotypes. This brings us to a critical question of whether rare haplotypes play an important role in influencing disease susceptibility and thus...
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