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Article

VKORC1 common variation and bone mineral density in the Third National Health and Nutrition Examination Survey.

PloS one - 13 Dec 2010

Crawford Dana C, Brown-Gentry Kristin, Rieder Mark J

Abstract excerpt

Osteoporosis, defined by low bone mineral density (BMD), is common among postmenopausal women. The distribution of BMD varies across populations and is shaped by both environmental and genetic factors. Because the candidate gene vitamin K epoxide reductase complex subunit 1 (VKORC1) generates vitamin K quinone, a cofactor for the gamma-carboxylation of bone-related proteins such as osteocalcin, we hypothesized...

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Identifiers

PMID: 21179439
DOI: 10.1371/journal.pone.0015088
PMCID: PMC3001474

Genes

VKORC1

Provenance

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