Article
Association of NFKBIA polymorphism with colorectal cancer risk and prognosis in Swedish and Chinese populations.
Scandinavian journal of gastroenterology - 1 Mar 2007
Gao Jingfang, Pfeifer Daniella, He Lu-Jun, Qiao Fang, Zhang Zhiyong, Arbman Gunnar, Wang Zhen-Lei, Jia Cun-Rong, Carstensen John, Sun Xiao-Feng
Abstract excerpt
OBJECTIVE: The inhibitory proteins, IkappaBs, regulate the activity of nuclear factor kappa-beta (NF-kappaB), which is implicated in tumorigenesis by regulating expression of a variety of genes involved in cellular transformation, proliferation, invasion, angiogenesis and metastasis. Variants in the genes encoding IkappaBs may be involved in cancer development through the activation of NF-kappaB. The objective of...
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