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Article

Effects of NFKB1 and NFKBIA gene polymorphisms on hepatocellular carcinoma susceptibility and clinicopathological features.

PloS one - 1 Jan 2013

Cheng Chao-Wen, Su Jen-Liang, Lin Chiao-Wen, Su Chun-Wen, Shih Chun-Han, Yang Shun-Fa, Chien Ming-Hsien

Abstract excerpt

BACKGROUND: Constitutive activation of nuclear factor (NF)-κB is frequently observed in hepatocellular carcinoma (HCC). The current study examined associations of polymorphisms within promoter regions of NFKB1 encoding NF-κB1 and NFKBIA encoding IκBα with the susceptibility of developing HCC and clinicopathological characteristics of the tumors. METHODOLOGY AND PRINCIPAL FINDINGS: Genetic polymorphisms of NFKB1...

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Share to Carcinoma, Hepatocellular
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to I-kappa B Proteins

Share to Liver Neoplasms

Share to NF-kappa B p50 Subunit

Share to NF-KappaB Inhibitor alpha

Share to Promoter Regions, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 23457512
DOI: 10.1371/journal.pone.0056130
PMCID: PMC3573054

Genes

NFKB1
NFKBIA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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