Article
NFκB1 and NFκBIA polymorphisms are associated with increased risk for sporadic colorectal cancer in a southern Chinese population.
PloS one - 1 Jan 2011
Song Shunxin, Chen Dianke, Lu Jiachun, Liao Jiawei, Luo Yanxin, Yang Zuli, Fu Xinhui, Fan Xinjuan, Wei Yisheng, Yang Lei, Wang Lei, Wang Jianping
Abstract excerpt
BACKGROUND: Nuclear factor κB (NFκB) plays a key role in the regulation of apoptosis. The function of NFκB is inhibited by binding to NFκB inhibitor (IκB), and disruption of the balance of NFκB and IκB is related to the development of many diseases, including tumors. Therefore, we hypothesized that the NFκB1 (-94del/insATTG) and NFκBIA (2758 A>G) polymorphisms were associated with colorectal cancer (CRC)...
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