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Article

Genetic variation and alterations of genes involved in NFκB/TNFAIP3- and NLRP3-inflammasome signaling affect susceptibility and outcome of colorectal cancer.

Carcinogenesis - 1 Nov 2012

Ungerbäck Jonas, Belenki Dimitri, Jawad ul-Hassan Aksa, Fredrikson Mats, Fransén Karin, Elander Nils, Verma Deepti, Söderkvist Peter

Abstract excerpt

Colorectal tumors are continuously exposed to an inflammatory environment, which together with mitogenic signals sustain several cancer hallmarks. Nuclear factor-kappa B (NFκB) is a major regulator of inflammation and variation in NFκB-associated genes could potentially be used as biomarkers to identify patients with increased risk of colorectal cancer (CRC) development, and/or a rapidly progressing disease. In...

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Source

Identifiers

PMID: 22843550
DOI: 10.1093/carcin/bgs256

Genes

TNFAIP3
NLRP3

Variants

rs6920220

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 3 Sept 2026.

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