Article
Association of the diplotype configuration at the N-acetyltransferase 2 gene with adverse events with co-trimoxazole in Japanese patients with systemic lupus erythematosus.
Arthritis research & therapy - 1 Jan 2007
Soejima Makoto, Sugiura Tomoko, Kawaguchi Yasushi, Kawamoto Manabu, Katsumata Yasuhiro, Takagi Kae, Nakajima Ayako, Mitamura Tadayuki, Mimori Akio, Hara Masako, Kamatani Naoyuki
Abstract excerpt
Although co-trimoxazole (trimethoprim-sulphamethoxazole) is an effective drug for prophylaxis against and treatment of Pneumocystis pneumonia, patients often experience adverse events with this combination, even at prophylactic doses. With the aim being to achieve individual optimization of co-trimoxazole therapy in patients with systemic lupus erythematosus (SLE), we investigated genetic polymorphisms in the...
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