The arylamine N-acetyltransferase (NAT2) polymorphism and the risk of adverse reactions to co-trimoxazole in children.

doi:10.1007/s002280050551

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Article

The arylamine N-acetyltransferase (NAT2) polymorphism and the risk of adverse reactions to co-trimoxazole in children.

European journal of clinical pharmacology - 1 Jan 2000

Zielińska E, Niewiarowski W, Bodalski J

Abstract excerpt

OBJECTIVE: The evaluation of the importance of the genetically determined acetylation defect for the development of adverse reactions to co-trimoxazole in children. METHODS: The study comprised 48 children aged 3 months to 3 years, who were being treated for interstitial pneumonia with co-trimoxa...

Topics

Acetylation
Alleles
Anti-Infective Agents
Arylamine N-Acetyltransferase
Child, Preschool
Female
Genotype
Humans
Infant
Male
Polymerase Chain Reaction
Polymorphism, Genetic
Risk Factors
Trimethoprim, Sulfamethoxazole Drug Combination

Source

Open in PubMed

Identifiers

PMID: 9923584
DOI: 10.1007/s002280050551

Genes

NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-9923584-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.

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