Article
NAT2 6A, a haplotype of the N-acetyltransferase 2 gene, is an important biomarker for risk of anti-tuberculosis drug-induced hepatotoxicity in Japanese patients with tuberculosis.
World journal of gastroenterology - 7 Dec 2007
Higuchi Norihide, Tahara Naoko, Yanagihara Katsunori, Fukushima Kiyoyasu, Suyama Naofumi, Inoue Yuichi, Miyazaki Yoshitsugu, Kobayashi Tsutomu, Yoshiura Kohichiro, Niikawa Norio, Wen Chun-Yang, Isomoto Hajime, Shikuwa Saburou, Omagari Katsuhisa, Mizuta Yohei, Kohno Shigeru, Tsukamoto Kazuhiro
Abstract excerpt
AIM: To investigate an association between N-acetyltransferase 2 (NAT2)-haplotypes/diplotypes and adverse effects in Japanese pulmonary tuberculosis patients. METHODS: We studied 100 patients with pulmonary TB treated with anti-TB drugs including INH. The frequencies and distributions of single n...
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