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Article

Arylamine N-acetyltransferase polymorphisms in Han Chinese patients with ankylosing spondylitis and their correlation to the adverse drug reactions to sulfasalazine.

BMC pharmacology & toxicology - 21 Nov 2014

Hou Zhi-duo, Xiao Zheng-yu, Gong Yao, Zhang Yu-ping, Zeng Qing Yu

Abstract excerpt

BACKGROUND: Polymorphisms of Arylamine N-acetyltransferase (NAT) that contribute to diverse susceptibilities of some autoimmune diseases are also linked to the metabolism of several drugs including sulfasalazine (SSZ). The aim of this study was to investigate the distribution of NAT polymorphisms in Han Chinese patients with ankylosing spondylitis (AS) and their correlation to sulfasalazine-induced adverse drug...

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Source

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Identifiers

PMID: 25413361
DOI: 10.1186/2050-6511-15-64
PMCID: PMC4247704

Genes

NAT1
NAT2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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