Article
Validation of the associations between single nucleotide polymorphisms or haplotypes and responses to disease-modifying antirheumatic drugs in patients with rheumatoid arthritis: a proposal for prospective pharmacogenomic study in clinical practice.
Pharmacogenetics and genomics - 1 Jun 2007
Taniguchi Atsuo, Urano Wako, Tanaka Eiichi, Furihata Shiori, Kamitsuji Shigeo, Inoue Eisuke, Yamanaka Mariko, Yamanaka Hisashi, Kamatani Naoyuki
Abstract excerpt
BACKGROUND: For prevention of joint destruction in rheumatoid arthritis, optimal management of therapy with disease-modifying antirheumatic drugs is essential. Pharmacogenomic evidence, if reliable, may be incorporated in the treatment of rheumatoid arthritis to achieve a more efficient activity control with minimized adverse events. METHODS: We conducted retrospective studies to validate our previous three...
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