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Article

Multiple Functions of the IKK-Related Kinase IKKε in Interferon-Mediated Antiviral Immunity

2 Mar 2007

Abstract excerpt

IKKepsilon is an IKK (inhibitor of nuclear factor kappaBkinase)-related kinase implicated in virus induction of interferon-beta (IFNbeta). We report that, although mice lacking IKKepsilon produce normal amounts of IFNbeta, they are hypersusceptible to viral infection because of a defect in the IFN signaling pathway. Specifically, a subset of type I IFN-stimulated genes are not activated in the absence of...

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PMID: 17332413
DOI: 10.1126/science.1136567

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