Article
Regulation of IFN-alpha/beta genes: evidence for a dual function of the transcription factor complex ISGF3 in the production and action of IFN-alpha/beta.
Genes to cells : devoted to molecular & cellular mechanisms - 1 Nov 1996
Harada H, Matsumoto M, Sato M, Kashiwazaki Y, Kimura T, Kitagawa M, Yokochi T, Tan R S, Takasugi T, Kadokawa Y, Schindler C, Schreiber R D, Noguchi S, Taniguchi T
Abstract excerpt
BACKGROUND: Efficient production of interferons (IFNs) in virally infected cells is an essential aspect of the host defence. The transcription factor complex ISGF3 (IFN-stimulated gene factor 3) was originally identified as a critical mediator of the IFN signal; it is formed upon IFN receptor (IF...
Topics
- Animals
- Base Sequence
- Cells, Cultured
- DNA-Binding Proteins
- Embryo, Mammalian
- Fibroblasts
- Gene Expression Regulation
- Interferon Type I
- Interferon-Stimulated Gene Factor 3
- Interferon-Stimulated Gene Factor 3, gamma Subunit
- Mice
- Mutation
- Newcastle disease virus