Article
IKKε modulates RSV-induced NF-κB-dependent gene transcription.
Virology - 20 Dec 2010
Bao Xiaoyong, Indukuri Hemalatha, Liu Tianshuang, Liao Sui-Ling, Tian Bing, Brasier Allan R, Garofalo Roberto P, Casola Antonella
Abstract excerpt
Respiratory syncytial virus (RSV), a negative-strand RNA virus, is the most common cause of epidemic respiratory disease in infants and young children. RSV infection of airway epithelial cells induces the expression of immune/inflammatory genes through the activation of a subset of transcription factors, including Nuclear Factor-κB (NF-κB). In this study we have investigated the role of the non canonical IκB...
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