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Article

The interferon system and interferon regulatory factor transcription factors -- studies from gene knockout mice.

Cytokine & growth factor reviews - 1 Jan 2000

Sato M, Taniguchi T, Tanaka N

Abstract excerpt

Interferon regulatory factors (IRFs) were initially identified as regulators of IFN-alpha/beta genes and to date nine members have been determined in human and mouse. They share a conserved DNA-binding domain in the N-terminal portion that recognizes similar DNA sequences. Despite their similar DNA binding specificity, the IRFs show diverse functions in response to extra cellular stimuli. Although the study of...

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PMID: 11325597
DOI: 10.1016/s1359-6101(00)00032-0

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