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Article

Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit.

Science (New York, N.Y.) - 25 Jun 2004

Ducut Sigala Jeanette L, Bottero Virginie, Young David B, Shevchenko Andrej, Mercurio Frank, Verma Inder M

Abstract excerpt

The nuclear factor-kappa B (NF-kappaB) family of transcription factors plays a seminal role in inflammation, apoptosis, development, and cancer. Modulation of NF-kappaB-mediated gene expression in response to diverse signals is coordinated by the IkappaB kinase (IKK) complex. We identified ELKS,...

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Identifiers

PMID: 15218148
DOI: 10.1126/science.1098387

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026. Prepared record publication-15218148-2026-09-01.1. Manifest publication-graph-cohort-2026-09-01.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 1 Sept 2026.

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