Article
Activation of transcription factor NF-kappaB requires ELKS, an IkappaB kinase regulatory subunit.
Science (New York, N.Y.) - 25 Jun 2004
Ducut Sigala Jeanette L, Bottero Virginie, Young David B, Shevchenko Andrej, Mercurio Frank, Verma Inder M
Abstract excerpt
The nuclear factor-kappa B (NF-kappaB) family of transcription factors plays a seminal role in inflammation, apoptosis, development, and cancer. Modulation of NF-kappaB-mediated gene expression in response to diverse signals is coordinated by the IkappaB kinase (IKK) complex. We identified ELKS, an essential regulatory subunit of the IKK complex. Silencing ELKS expression by RNA interference blocked induced...
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