Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The IKK complex, a central regulator of NF-kappaB activation.

Cold Spring Harbor perspectives in biology - 1 Mar 2010

Israël Alain

Abstract excerpt

The IKK kinase complex is the core element of the NF-kappaB cascade. It is essentially made of two kinases (IKKalpha and IKKbeta) and a regulatory subunit, NEMO/IKKgamma. Additional components may exist, transiently or permanently, but their characterization is still unsure. In addition, it has been shown that two separate NF-kappaB pathways exist, depending on the activating signal and the cell type, the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Dimerization
Share to Gene Expression Regulation
Share to I-kappa B Kinase

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Models, Biological

Share to NF-kappa B

Share to Protein Structure, Tertiary

Share to Time Factors

Share to Zinc Fingers

Source

Open in PubMed Open full text

Identifiers

PMID: 20300203
DOI: 10.1101/cshperspect.a000158
PMCID: PMC2829958

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The IKK complex, a central regulator of NF-kappaB activation.PMID 20300203Read ↗

IKK-related genetic diseases: probing NF-κB functions in humans and other matters.Semantic proximity Read ↗

THE NF-κB AND IκB PROTEINS: New Discoveries and InsightsSemantic proximity Read ↗

NF-κB: a key role in inflammatory diseasesSemantic proximity Read ↗

Circuitry of nuclear factor κB signalingSemantic proximity Read ↗

Direct phosphorylation of IkappaB by IKKalpha and IKKbeta: discrimination between free and NF-kappaB-bound substrate.Semantic proximity Read ↗

Function of Nuclear Factor Kappa B (NF-kB) in Human Diseases-A ReviewSemantic proximity Read ↗

The Nuclear Factor Kappa B (NF-kB) signaling in cancer development and immune diseasesSemantic proximity Read ↗

NF-κB inducing kinase: A key regulator in the immune system and in cancerSemantic proximity Read ↗

The NF-κB regulator IκBβ exhibits different molecular interactivity and phosphorylation status from IκBα in an IKK2-catalysed reaction.Semantic proximity Read ↗

Attribution of NF-κB Activity to CHUK/IKKα-Involved CarcinogenesisSemantic proximity Read ↗

Nuclear Factor-Kappa B: From Clone to ClinicSemantic proximity Read ↗

The central inflammatory regulator IκBζ: induction, regulation and physiological functionsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.