Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis.

The Journal of experimental medicine - 7 Jun 1999

Li Z W, Chu W, Hu Y, Delhase M, Deerinck T, Ellisman M, Johnson R, Karin M

Abstract excerpt

The IkappaB kinase (IKK) complex is composed of three subunits, IKKalpha, IKKbeta, and IKKgamma (NEMO). While IKKalpha and IKKbeta are highly similar catalytic subunits, both capable of IkappaB phosphorylation in vitro, IKKgamma is a regulatory subunit. Previous biochemical and genetic analyses have indicated that despite their similar structures and in vitro kinase activities, IKKalpha and IKKbeta have distinct...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Apoptosis
Share to I-kappa B Kinase

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Interleukin-1

Share to NF-kappa B

Share to Protein Conformation

Share to Protein Serine-Threonine Kinases

Share to Tumor Necrosis Factor-alpha

Source

Open in PubMed Open full text

Identifiers

PMID: 10359587
DOI: 10.1084/jem.189.11.1839
PMCID: PMC2193082

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The IKKbeta subunit of IkappaB kinase (IKK) is essential for nuclear factor kappaB activation and prevention of apoptosis.PMID 10359587Read ↗

Positive and negative regulation of IkappaB kinase activity through IKKbeta subunit phosphorylation.Semantic proximity Read ↗

Abnormal morphogenesis but intact IKK activation in mice lacking the IKKalpha subunit of IkappaB kinase.Semantic proximity Read ↗

IkappaBalpha deficiency results in a sustained NF-kappaB response and severe widespread dermatitis in mice.Semantic proximity Read ↗

Genetic approaches in mice to understand Rel/NF-kappaB and IkappaB function: transgenics and knockouts.Semantic proximity Read ↗

IκB kinase (IKK)β, but not IKKα, is a critical mediator of osteoclast survival and is required for inflammation-induced bone lossSemantic proximity Read ↗

IkappaB kinase alpha (IKKalpha) regulation of IKKbeta kinase activity.Semantic proximity Read ↗

IKK1-deficient mice exhibit abnormal development of skin and skeleton.Semantic proximity Read ↗

The IkappaB kinase - a bridge between inflammation and cancer.Semantic proximity Read ↗

IKKbeta leads to an inflammatory skin disease resembling interface dermatitis.Semantic proximity Read ↗

The IKK complex, a central regulator of NF-kappaB activation.Semantic proximity Read ↗

IKK-related genetic diseases: probing NF-κB functions in humans and other matters.Semantic proximity Read ↗

The carboxyl-terminal region of IkappaB kinase gamma (IKKgamma) is required for full IKK activation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.