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Article

STAT3 Negatively Regulates Type I IFN-Mediated Antiviral Response

2 Aug 2011

Abstract excerpt

Type I IFNs are crucial cytokines of innate immunity for combating viral infections. Signaling through type I IFN receptors triggers the activation of STAT proteins, including STAT1, STAT2, and STAT3. Although an essential role of STAT1 and STAT2 for type I IFN-induced antiviral response has been well established by studies of gene-targeted mice and human mutations, the role of STAT3 for this response remains...

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PMID: 21810606
DOI: 10.4049/jimmunol.1004128

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