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Article

IKK-i signals through IRF3 and NFkappaB to mediate the production of inflammatory cytokines.

Cellular signalling - 1 Jul 2006

Sankar Sabita, Chan Henry, Romanow William J, Li Jianwu, Bates R J

Abstract excerpt

IKK-i and TBK1 were recently identified as IKK-related kinases that are activated by toll-like receptors TLR3 and TLR4. These kinases were identified as essential components of the virus-activated as well as LPS-MyD88 independent kinase complex that phosphorylates IRF3 and results in the production of cytokines involved in innate immunity. Both IKK-i and TBK1 have also been implicated in the activation of the...

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Source

Identifiers

PMID: 16199137
DOI: 10.1016/j.cellsig.2005.08.006

Genes

TBK1
TLR3
TLR4
JAK1
STAT1
TNF

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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