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Article

Persistent initiation of DNA replication and chromatin-bound MCM proteins during the cell cycle in cdc6 mutants.

Genes & development - 15 Dec 1997

Liang C, Stillman B

Abstract excerpt

Faithful inheritance of genetic information requires that DNA be copied only once each cell cycle. Initiation of DNA replication involves the establishment of a prereplication complex (pre-RC) and subsequent activation by CDK/cyclins, converting the pre-RC to a post-RC. The origin recognition complex (ORC), Cdc6p, and the MCM proteins are required for establishing the pre-RC. We show that all six ORC subunits...

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Identifiers

PMID: 9407030
DOI: 10.1101/gad.11.24.3375
PMCID: PMC316796

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Source receipt: pubmed, retrieved 7 Sept 2026.

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