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Article

Thyroid hormone response element organization dictates the composition of active receptor.

The Journal of biological chemistry - 27 Apr 2007

Velasco Lara F R, Togashi Marie, Walfish Paul G, Pessanha Rutinéia P, Moura Fanny N, Barra Gustavo B, Nguyen Phuong, Rebong Rachelle, Yuan Chaoshen, Simeoni Luiz A, Ribeiro Ralff C J, Baxter John D, Webb Paul, Neves Francisco A R

Abstract excerpt

Thyroid hormone (triiodothyronine, T(3)) is known to activate transcription by binding heterodimers of thyroid hormone receptors (TRs) and retinoid X receptors (RXRs). RXR-TRs bind to T(3) response elements (TREs) composed of direct repeats of the sequence AGGTCA spaced by four nucleotides (DR-4). In other TREs, however, the half-sites can be arranged as inverted palindromes and palindromes (Pal). Here we show...

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PMID: 17311926
DOI: 10.1074/jbc.M610700200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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