Article
Thyroid hormone receptor homodimers can function as ligand-sensitive repressors.
Molecular endocrinology (Baltimore, Md.) - 1 May 1995
Piedrafita F J, Bendik I, Ortiz M A, Pfahl M
Abstract excerpt
Unlike the steroid hormone receptors that bind their response elements as homodimers, thyroid hormone receptor (TRs) as well as retinoic acid receptors and several other receptors have been shown to require heterodimerization with retinoid X receptors (RXR) for efficient binding to most response elements. In this article we have compared in detail TR DNA binding and its gene-regulatory characteristics in the...
Topics
- Animals
- Base Sequence
- Binding Sites
- DNA
- Ligands
- Molecular Sequence Data
- Mutation
- Promoter Regions, Genetic
- Proto-Oncogene Proteins
- Rabbits
- Receptors, Retinoic Acid