Article
N-terminal variants of thyroid hormone receptor beta: differential function and potential contribution to syndrome of resistance to thyroid hormone.
Molecular endocrinology (Baltimore, Md.) - 1 Sept 1995
Ng L, Forrest D, Haugen B R, Wood W M, Curran T
Abstract excerpt
The human syndrome of resistance to thyroid hormone (RTH) is associated with dominant mutations in the thyroid hormone receptor beta (TR beta) gene that generate mutant receptors with impaired binding for T3. Although the TR beta gene differentially expresses two N-terminal variant receptors, TR beta 1 and TR beta 2, functional analyses of RTH mutants have focused exclusively on TR beta 1. Since TR beta 2 is...
Topics
- 3T3 Cells
- Animals
- Base Sequence
- Binding Sites
- Cell Line
- DNA
- Drug Resistance
- Humans
- Macromolecular Substances
- Mice
- Molecular Sequence Data