Article
Half-site spacing and orientation determines whether thyroid hormone and retinoic acid receptors and related factors bind to DNA response elements as monomers, homodimers, or heterodimers.
Molecular endocrinology (Baltimore, Md.) - 1 Mar 1992
Forman B M, Casanova J, Raaka B M, Ghysdael J, Samuels H H
Abstract excerpt
The receptors for thyroid hormone (T3R) and retinoic acid (RAR) are members of a nuclear receptor subfamily that are capable of recognizing similar DNA sequences. Native response elements for T3R and RAR consist of two or more putative half-site binding motifs organized as imperfect direct or inv...
Topics
- Base Sequence
- Binding Sites
- Carrier Proteins
- DNA
- HeLa Cells
- Humans
- Macromolecular Substances
- Molecular Sequence Data
- Mutation
- Nuclear Proteins
- Nucleic Acid Conformation
- Receptors, Glucocorticoid
- Receptors, Retinoic Acid
- Receptors, Thyroid Hormone