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Article

Different DNA elements can modulate the conformation of thyroid hormone receptor heterodimer and its transcriptional activity.

The Journal of biological chemistry - 20 Sept 1996

Ikeda M, Wilcox E C, Chin W W

Abstract excerpt

Thyroid-hormone receptors (TRs) form heterodimers with retinoid-X receptors (RXRs) on thyroid-hormone-response elements (TREs). However, it is not known whether the formation of liganded TR/RXR heterodimer on a TRE alone is sufficient to dictate transcriptional activity. We designed several mutated DR4s (half-sites arranged as direct repeats with a nucleotide gap of 4) that bound TR/RXR heterodimers...

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Source

Identifiers

PMID: 8798500
DOI: 10.1074/jbc.271.38.23096

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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