Article
Different DNA elements can modulate the conformation of thyroid hormone receptor heterodimer and its transcriptional activity.
The Journal of biological chemistry - 20 Sept 1996
Ikeda M, Wilcox E C, Chin W W
Abstract excerpt
Thyroid-hormone receptors (TRs) form heterodimers with retinoid-X receptors (RXRs) on thyroid-hormone-response elements (TREs). However, it is not known whether the formation of liganded TR/RXR heterodimer on a TRE alone is sufficient to dictate transcriptional activity. We designed several mutat...
Topics
- Binding Sites
- DNA Footprinting
- Gene Expression Regulation
- Mutation
- Oligonucleotide Probes
- Protein Binding
- Protein Conformation
- Receptors, Retinoic Acid
- Receptors, Thyroid Hormone
- Regression Analysis
- Regulatory Sequences, Nucleic Acid
- Repetitive Sequences, Nucleic Acid
- Retinoid X Receptors
- Transcription Factors
- Transcription, Genetic
- Triiodothyronine